Reducing Execution Errors in Cell Therapeutics Manufacturing

In an earlier post, Managing the Chain of Identity in Cell Therapeutics Manufacturing, we highlighted how the manufacturing process of these cell therapies must be performed with absolute accuracy the first time since each batch is produced for a specific patient. It’s critical during the production process that any execution errors be identified and corrected before completion. Any errors in development, manufacturing, or documentation can mean a missed treatment window for patients as well as financial and regulatory consequences for cell therapeutics manufacturers.

Emerson's Bob Schiros


Emerson’s Bob Schiros described how manufacturing execution systems, such as Syncade MES, help to reduce errors and deviations by automating manual procedures, integrating with other systems, automating calculations, and reviewing in-process data during the running batch. By automating workflows and improved electronic manufacturing, critical errors can be avoided or caught early enough to correct.

A well-designed and integrated manufacturing execution system helps reduce process errors by verifying materials, samples, process manipulations, and equipment. Calculation errors, occasionally introduced when performed manually during the batch run, are eliminated by automating the calculations. Continue Reading

Digital Twin for Increased Project and Operational Performance

You may have been seeing the phrase “Digital Twin” more and more in the automation and industry press. Wikipedia defines the Digital twin concept as:

…a digital replica of physical assets, processes and systems that can be used for various purposes.[1] The digital representation provides both the elements and the dynamics of how an Internet of Things device operates and lives throughout its life cycle.[2]

Emerson's Ronnie Bains


In a LinkedIn post, Digital Twin Streamlines Regulatory Compliance in Life Sciences, Emerson’s Ronnie Bains describes how a dynamic simulation provides a software-based digital twin of a production facility.

He notes that these dynamic simulations have not been traditionally been deployed in pharmaceutical and biotech manufacturing operations [hyperlink added]:

…however using Emerson’s Mimic simulation technology, a new standard of simulation technology, perfectly suited to the Life Sciences industry is feasible.

Projects and ongoing operations can be streamlined by developing the digital twin during the initial design phase and using it in: Continue Reading

IIoT in Steps for Monitoring Valve Health

Emerson's Jonas Berge


Manufacturers and producers can improve safety, reliability and efficiency by applying additional sensors, analytics and experts. Difficulties in installation have held back these improvements, but the Industrial Internet of Things (IIoT) technologies have significantly reduced these barriers.

Valve magazine: Monitoring Valve Health via the InternetOne example of IIoT in action is featured in a Valve magazine article, Monitoring Valve Health via the Internet.

Emerson’s Jonas Berge opens the article:

Most valve end users are already using smart valve positioners on some control valves, but they may not have time to check the valve diagnostics software to notice if any valves are developing problems. Imagine instead simply getting a weekly report listing which valves need attention.

Jonas explains that the Industrial Internet of Things opens the ability to get these diagnostics into the right hands wherever the valve experts are located. These could be in-house valve experts, perhaps located remotely, or provided as a service by the valve supplier.

Jonas describes a step-by-step approach: Continue Reading

Adding Wireless Level Switches for Storage Tank Overfill Prevention

Control Engineering Asia: Wireless vibrating fork technology enables Hengyang Petrochemical to implement cost-effective overfill prevention solutionStorage tanks holding volatile fluids must have reliable level measurements to avoid unsafe overfill conditions. A Control Engineering Asia article, Wireless vibrating fork technology enables Hengyang Petrochemical to implement cost-effective overfill prevention solution, describes how this petrochemical producer sought to reduce the risk of overfill conditions.

The plant had existing non-contacting radar level measurement devices to measure continuous level changes but wanted to comply with a recent industry standard for the additional use of an independent overfill prevention sensor. The plant engineering staff approached the Emerson team for a recommendation.

A solution based on vibrating forks was recommended because the technology is less prone to failure and requires minimal maintenance.

The [hyperlink added]:

Rosemount™ 2160 Wireless Vibrating Fork Level Switches were selected to provide overfill prevention. The industry’s first WirelessHART® point level switch enables level detection to be made in locations previously inaccessible or cost-prohibitive for wired devices.

Device health diagnostics in these level switches include: Continue Reading

Connecting the Experts More Closely to You

It’s been a light posting week. I’ve been in Houston working with Emerson subject matter experts from across many of the Emerson Automation Solutions business units. Look for a number of new Emerson voices sharing their expertise here on the blog and in Emerson Exchange 365, LinkedIn and Twitter.

Here’s a few photos of the group from our sessions at the Emerson Actuation Technologies global headquarters office.

Emerson Social subject matter experts

Make sure to join Emerson Exchange 365 and join the groups in your areas of interest to connect with these and many more of the subject matter experts around Emerson.

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